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2.4 Metformin and drug transporter proteins Metformin exhibits a relatively modest oral bioavailability, ranging from 50% to 60% ( 14 C-labeled metformin is absorbed in the small intestine, with 20% being absorbed in the duodenum and 60% in the jejunum and ileum combined (Vidon et al., 1988
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The vast majority came from people eating less because their appetite was suppressed
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